ox.st

Hair loss and depression

oxst — Tue, 20 Jul 2010 20:14:55 +0000

Psychiatr Danub. 2010 Jun;22(2):293-5.

Depressive disorder and alopecia.

Grahovac T, Ruzi? K, Sepi?-Grahovac D, Dadi?-Hero E, Radonja AP.

Psychophysical dermatitis is frequently manifested in patients that suffer from
psychiatric illnesses and disorders as well as in patients that suffer from
depressive disorders. These diseases occur or worsen after acute stress that may
trigger them. Difficulties in expressing feelings or impossibility to verbalise
them are connected to somatic diseases. In order to emphasize their importance,
we will present a case of a 58 years old woman who has been suffering from
alopecia areata that developed after her husband’s death. The patient doesn’t
function well since then – she is socially isolated, she has lost self confidence
and self esteem. As she has realised it was impossible to live like that, she
decided to seek psychiatric help. The patient should be examined through the
prism of the interdisciplinary treatment and as an integral structure of the mind
and body.

hair loss regrowth and hair loss treatment

Erectile dysfunction and finasteride

oxst — Sat, 01 May 2010 17:48:59 +0000

The effect of 5 alpha-reductase inhibitors on erectile function.

Canguven O, Burnett AL.

The 5 alpha-reductase inhibitors, which inhibit conversion of testosterone to dihydrotestosterone, are used for miscellaneous clinical applications, including the treatment of benign prostatic hyperplasia and male pattern hair loss, and for possible reduction of the risk of prostate cancer. Erectile dysfunction has been associated with 5 alpha-reductase inhibitors. Overall, reports in the literature suggest rates of erectile dysfunction to be between 0.8%-33% in men using these medications. However, randomized controlled studies report the rates of erectile dysfunction to be between 0.8%-15.8%. ….snip…. In this review, we surveyed studies on erectile dysfunction in patients treated with 5 alpha-reductase inhibitors and critically examined the evidence that associates 5 alpha-reductase inhibitors and erectile dysfunction. We conclude that 5 alpha-reductase inhibitors do not lead to erectile dysfunction to a significant degree, and we support the position that dihydrotestosterone is less relevant than testosterone in erectile function.

Hair loss treatment

oxst — Tue, 23 Mar 2010 20:59:03 +0000

Hair loss treatment at the Proctor clinic

Uric acid and stroke

oxst — Sun, 13 Dec 2009 03:29:13 +0000

Dr Proctor has published research papers on Uric acid and stroke.

Estrogen effects on hair regrowth

oxst — Wed, 02 Dec 2009 19:50:31 +0000

Eur J Dermatol. 2001 May-Jun;11(3):195-8.

Niiyama S, Happle R, Hoffmann R.

he molecular pathways involved in estrogen-mediated induction of hair regrowth in androgenetic alopecia or male pattern hair loss are unknown. Some authors found that estradiol (E) inhibited 5alpha-reductase (5alpha-R) activity and therefore we addressed the question whether 17alpha- or 17beta-E are able to modulate the activity of 5alpha-R, 3beta-hydroxysteroid dehydrogenase (3beta-HSD) or 17beta-hydroxysteroid dehydrogenase in human hair follicles. For this purpose, scalp biopsies from volunteers were taken and from each biopsy root sheaths, connective tissue sheaths and dermal papillae were dissected and incubated in the presence of 3H-testosterone and, in addition, either 17alpha-E, 17beta-E, progesterone or finasteride for up to 48 hrs. Thereafter high-performance liquid chromatography analysis of culture supernatants was performed to detect T-metabolites.

Cutaneous manifestations of diabetes

oxst — Wed, 25 Nov 2009 18:30:10 +0000

indian J Dermatol Venereol Leprol. 2003;69:105

Cutaneous manifestation of diabetes mellitus.

Mahajan S, et al

One hundred consecutive diabetes mellitus patients attending the diabetic clinic of the hospital constituted the study group. One hundred age and sex matched non-diabetics were taken as controls. The majority, 63%, belonged to the 41-60 years age group and 98% had non-insulin dependent diabetes. Among the study group, 64% had one or more cutaneous manifestations as compared to 22% in the controls. Infections comprised the largest group affecting 35 of the 64 cases. snip….Likewise syndromes of insulin resistance were seen in 4 patients of whom 3 had aconthosis nigricans and one had congenital lipodystrophy. Furthermore, 9 patients had dermatoses known to be associated with an increased incidence of diabetes; vitiligo in 4, acquired perforating dermatoses in 3, and lichen planus in 2. Four patients had dermatoses known to be associated with diabetes: psoriasis in 3 and diffuse alopecia in one. Three had adverse drug reactions to anti-diabetic therapy.

Dr Proctor adds: We have found hair loss in diabetes in experimental animals

Hair loss blogs

oxst — Tue, 17 Nov 2009 17:31:25 +0000

Hair Loss Blog Hair Loss Blog blog Hair Loss Blog Hair regrowth Blog blog blog

Estrogen treatment of hair loss

oxst — Wed, 11 Nov 2009 01:43:48 +0000

local estrogen application in male pattern hair loss

[Article in German]

Orfanos CE, Wüstner H.

In 30 male patients aged 17-37 with definite androgenetic (”male pattern”) alopecia (”hair loss”) the total urinary estrogen level was estimated before and after topical treatment: In 18 patients estrogen in a alcoholic vehicle was daily applied on the scalp skin; whereas 12 patients served as controls. Before treatment the average estrogen level of all patients with AA was 23.3 mum/24 hrs (individual data ranged from 9.4-45.6 mum/24 hrs) and was thus slightly elevated but still within the normal range. 3 and 6 months after treatment no significant differences of the urinary estrogen level were found between the controlled patients of the two groups and, similarly, no clinical side-effects of the estrogen application (gynecomasty etc.) were recorded. It seems, on the basis of this study, that a long-term topical treatment of hair loss with estrogen does not involve considerable risks regarding side-effects on male adults, in contrast to children and youngsters. snip….

Edited for blog

5-AR in skin

oxst — Sat, 24 Oct 2009 01:20:31 +0000

J Invest Dermatol. 1987;89(1):87

Is increased 5 alpha-reductase activity a primary phenomenon in androgen-dependent skin disorders?

Dijkstra AC, et al

Testosterone metabolism was investigated in fractions of human skin, enriched in epidermis, dermis, sebaceous glands, and sweat glands, by histologic sectioning of skin punch biopsies, and the results were compared with two culturable skin cells, …snip… In the deeper skin layers the formation of androstenedione was markedly reduced, whereas the formation of 5 alpha-reduced metabolites was highly increased, with a maximum in the skin fractions containing large sebaceous glands. …snip…. The present approach, allowing the comparison of testosterone metabolism in different substructures of the same skin biopsy provides new evidence that the high 5 alpha-reductase activity in the specific skin fractions must be mainly ascribed to the sebaceous glands. These results render a previous hypothesis, stating that the elevated level of 5 alpha-reductase and subsequent formation of dihydrotestosterone in male pattern hair loss and acne (usually accompanied by seborrhea) could therefore simply be the consequence of sebaceous gland enlargement, much stronger.

Hair loss after maprotiline

oxst — Sun, 18 Oct 2009 14:08:45 +0000

Hautarzt. 1991;42(7):455

Ichthyosis and alopecia after maprotiline: corneolysis caused by temporary disorder of keratinization

Niederauer HH, Bacharach-Buhles M, Altmeyer P.

A 37-year-old woman developed ichthyosiform desquamation of the skin and a severe diffuse alopoecia 3 weeks after taking the antidepressant maprotilin. No signs of inflammation were present. Histology revealed acanthosis with preserved stratum granulosum, follicular hyperkeratosis and dystrophic changes of the hair follicle. Electron microscopy revealed rarefication of tonofilaments and necrobiotic changes of epidermal keratinocytes with vacuolar degeneration of the cytoplasm and disorganization of the organelles. Pathogenetically this disease represents a drug-induced transitory disorder to keratinization, which had resulted in desquamation of the stratum corneum and hair loss. The authors propose the designation corneolysis for this pathogenetic principle.