Archive for December, 2009

Uric acid and stroke

Sunday, December 13th, 2009

Dr Proctor has published research papers on Uric acid and stroke.

Estrogen effects on hair regrowth

Wednesday, December 2nd, 2009

Eur J Dermatol. 2001 May-Jun;11(3):195-8.

Niiyama S, Happle R, Hoffmann R.

he molecular pathways involved in estrogen-mediated induction of hair regrowth in androgenetic alopecia or male pattern hair loss  are unknown. Some authors found that estradiol (E) inhibited 5alpha-reductase (5alpha-R) activity and therefore we addressed the question whether 17alpha- or 17beta-E are able to modulate the activity of 5alpha-R, 3beta-hydroxysteroid dehydrogenase (3beta-HSD) or 17beta-hydroxysteroid dehydrogenase  in  human hair follicles. For this purpose, scalp biopsies from volunteers were taken and from each biopsy root sheaths, connective tissue sheaths and dermal papillae were dissected and incubated in the presence of 3H-testosterone  and, in addition, either 17alpha-E, 17beta-E, progesterone or finasteride for up to 48 hrs. Thereafter high-performance liquid chromatography analysis of culture supernatants was performed to detect T-metabolites.